Average Registered Nurse Salary in Indianapolis, IN

The average Registered Nurse in Indianapolis, IN earns $85,580 per year. See how this compares to the national average and what it means for your budget.

Average Salary
$85580
Median Salary
$80290
vs. National
9.4% below
Real Pay (COL-adjusted)
$89429

“Real pay” adjusts the average for Indianapolis’s cost of living (Regional Price Parity 95.696, U.S. average = 100) — what this salary is worth in national-average dollars.

What Registered Nurses actually earn in Indianapolis

The spread from entry-level (10th percentile) to top earners (90th), from BLS wage data.

10th (entry) $62930
25th $65830
Median $80290
75th $97740
90th (top) $103710

26510 Registered Nurses employed in the Indianapolis metro.

Can a Registered Nurse afford a home in Indianapolis?

Max home price under the 28% rule (housing ≤ 28% of gross), 10% down, 6.7% 30-yr rate. Median Indianapolis home: $207000.

Earnings levelSalaryMax homeMedian home?
Entry (10th)$62930$252840Yes
Median$80290$322589Yes
Top (90th)$103710$416685Yes

What’s this salary worth in another city?

What you earn (or want to compare)

Take-home pay for a Registered Nurse in Indianapolis

Estimated pay after federal, FICA, and IN state taxes (2026). Prefilled with the local average — adjust for your situation.

Estimate only — not tax advice. Tax year 2026, federal + FICA + state (single or married filing jointly). Excludes local/city income taxes (e.g., NYC, Philadelphia) and individual credits. See our methodology.

Indianapolis at a glance

Population882043
Median household income$62995
Median home value$207000
Median rent$1112/mo
Cost of living (RPP, U.S.=100)95.696
Bachelor’s degree or higher21.7%
Poverty rate15.4%

In Indianapolis, IN, Registered Nurses earn a median of $80,290 a year — about 15% below the U.S. median of $94,480. Among the 50 metros tracked here for this role, that ranks #39.

What that pay is worth in Indianapolis

Local prices run 96 on the BEA cost-of-living index (U.S. = 100), so a $85,580 salary stretches further than the sticker number — about $89,429 in national-average buying power.

Can Registered Nurses afford a home in Indianapolis?

A typical Indianapolis home runs about $207,000 — 2.4 times the average Registered Nurse salary, very affordable against the classic 3x rule of thumb. Median rent near $1,112/mo takes roughly 16% of gross pay — within the 30% comfort line.

The Registered Nurse pay ladder in Indianapolis

Entry-level (10th percentile) Registered Nurses earn about $62,930; the top 10% reach $103,710 — a $40,780 spread, moderate for this field. Most of that gap comes down to experience, employer, and how hard you negotiate.

The Registered Nurse job market in Indianapolis

Indianapolis employs roughly 26,510 Registered Nurses. It’s a sizable local market to build a career in.

Compare Indianapolis with other cities

See the full Registered Nurse salary by city ranking to weigh Indianapolis against the other metros on both pay and cost-adjusted value, or use the cost-of-living calculator to compare any two cities directly.

Frequently asked questions

How much do Registered Nurses make in Indianapolis?

The average Registered Nurse in Indianapolis, IN earns about $85,580 per year, 9.4% below the national average of $94,480.

What is the take-home pay for Registered Nurses in Indianapolis after taxes?

After federal and IN taxes, this $85,580 salary is worth about $66,510 a year - roughly $5,542 a month in take-home pay, an effective tax rate near 22%.

What do the highest-paid Registered Nurses earn in Indianapolis?

The top 10% of Registered Nurses in Indianapolis earn about $103,710 a year, versus about $62,930 for the bottom 10%.

Can Registered Nurses afford a home in Indianapolis?

A typical Indianapolis home runs about $207,000 - roughly 2.4x this salary, within reach by the classic 3x rule of thumb.

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